Diego Villar

Mammalian epigenomic conservation of promoters and enhancers in the heart associates with trait-associated variation and impacts cardiomyocyte phenotypes

The paper identifies epigenomically conserved promoters and enhancers in the heart, links them to cardiovascular trait variation, and shows their impact on cardiomyocyte phenotypes through experimental validation.

Coordinated shifts in gene expression and regulation during mole-rat evolution

The paper identifies accelerated gene expression and regulatory evolution in mole-rats by integrating transcriptomics and cis-regulatory analysis across species.

An epigenomic investigation of atrial fibrillation in a matched left and right atrial human cohort

This study investigates epigenomic changes in left and right atria of atrial fibrillation patients compared to controls, identifying dysregulated loci and epigenetic mechanisms.

Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits

The paper uses phylogenetic modeling to analyze epigenomic changes in mole-rats and identifies regulatory elements associated with metabolic and hypoxia-related traits.

DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts

The paper identifies DNA methylation patterns at TF binding sites across species, linking them to functional roles and evolutionary changes.

LINE elements are a reservoir of regulatory potential in mammalian genomes

The paper investigates how LINE elements contribute to the evolution of tissue-specific and shared regulatory regions across mammalian genomes.

Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression

The paper examines how regulatory landscapes influence gene expression stability across mammals, finding that conserved elements and element number are key to expression resilience.

Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

The paper generates a transcriptome resource and eQTL catalogue in vervet monkeys, revealing sex and age-related expression patterns and key regulatory loci.