Malini Natarajan

The paper shows that Lola-I, a Drosophila zinc finger transcription factor, regulates promoter accessibility and paused Pol II during development, similar to enhancer regulation by pioneer factors.

The paper compares TATA and paused promoters in Drosophila embryos, finding that TATA promoters show Pol II occupancy only when active, while paused promoters have consistent Pol II levels regardless of gene expression.

The paper maps transcription factor expression in Drosophila melanogaster pupal terminalia using RNA-seq and in situ hybridization, revealing structured patterns and creating an online database for future research.