Jay R. Unruh

One Drosophila Ref(2)P polypeptide takes different structures in midgut and muscle, driving autophagy or mitochondria-associated degradation; deleting disordered region IDR2 switches muscle Ref(2)P to midgut state.

This study investigates how variations in centromeric alpha-satellite array size affect centromere function during mitosis, finding that smaller arrays are more prone to missegregation and cohesion fatigue.

The paper shows that increasing translation initiation rates accelerates nucleation of aggregating proteins at polysomes, suggesting cotranslational nucleation influences proteome evolution.

This study shows TDP-43 amyloid forms only when its C-terminal domain arrests in soluble clusters, and this process can be inhibited by co-expressing an oligomeric binder.

The paper identifies a specific SNP in Cx50 linked to eye loss in cavefish using a hybrid population from a karst window.

This study identifies two distinct multicellular niches in fetal liver and adult bone marrow that support hematopoietic stem cells with different cycling states and lineage biases.

The paper identifies and characterizes intermediate states during neural crest cell epithelial to mesenchymal transition and delamination using single-cell RNA sequencing.

The paper investigates how shared retinoic acid response elements regulate nascent transcription of Hoxb genes in mouse neural tube development using smFISH.

The paper shows that disruptions in Pol I rRNA transcription specifically affect craniofacial development by causing NCC apoptosis and craniofacial anomalies in mice.

The paper shows that Lola-I, a Drosophila zinc finger transcription factor, regulates promoter accessibility and paused Pol II during development, similar to enhancer regulation by pioneer factors.

This study shows that budding yeast adapts to long-term high temperature by reducing temperature-sensitive proteins, relocalizing the proteome, and altering protein conformations, which may confer new functions.

The paper introduces SCAP, a method combining affinity purification, live cell imaging, and cross-linking mass spectrometry to build integrative structural models of protein complexes.

This study shows that X chromosomes and autosomes have different sensitivity to SC disruption in meiosis, indicating distinct regulatory mechanisms.

The paper shows that PCP and Wnt pathways independently control hair cell orientation in zebrafish lateral line, with Wnt mutants causing concentric patterns and PCP mutants causing random orientations.

The paper identifies combinatorial binding of Hoxa1 and TALE proteins on genome-wide targets and reveals their cross-regulatory interactions.