Author

Joseph A. Duncan

University of North Carolina at Chapel HillORCID 0000-0002-4438-2018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:DNA methylation· 1 Assay:flow cytometry· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Aleksandra E. SikoraiD· 1 shared Alison K. CrissiD· 1 shared Andreea WaltmanniD· 1 shared Andrew N. MacintyreiD· 1 shared Ann E. JerseiD· 1 shared Gerald S. ShadeliD· 1 shared Gregory D. BowmaniD· 1 shared Guannan Huang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

Aleksandra E. SikoraORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

cGAS bends unpaired DNA to form an unconventional structure that hyperactivates the innate immune response

Shuangshuang Yang, Shuai Wu, Silian Chen, Xin Li, Iryna Chelepis, Smaranda Willcox, Katherine Camille Barnett, Xiaoqing Hu, Guannan Huang, W. June Brickey, Joseph A. Duncan, Wei-Chun Chou, Pengda Liu, William G. Fusco, Stephanie Torres, , Jenny P.‐Y. Ting

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

bioRxiv · May 25, 2026 · PreprintImmunology

Protection against N. gonorrhoeae induced by OMV-based Meningococcal Vaccines are associated with cross-species directed humoral and cellular immune responses

Weiyan Zhu, Andreea Waltmann, Marguerite B. Little, Kristie L. Connolly, Kathryn Matthias, Keena S. Thomas, Mary C. Gray, Aleksandra E. Sikora, Alison K. Criss, Margaret C. Bash, Andrew N. Macintyre, Ann E. Jerse, Joseph A. Duncan

This study investigates cross-species immune responses induced by meningococcal OMV vaccines and their association with protection against N. gonorrhoeae.

Frontiers in Immunology · Apr 11, 2025Peer-reviewedMicrobiology