Microcephaly-like phenotype triggered by novel reassortant and prototypic Oropouche Virus strains in brain organoids
Gabrielle Brum Lopes da Silva, Vivian Grizente Rocha, Fábio Luís Lima Monteiro, Beatriz Luzia de Mello Lima Guimarães, Livia Goto‐Silva, João Marcos de Azevedo Delou, Pedro Junior Pinheiro Mourão, Ismael Carlos da Silva Gomes, Enzo Oliveira Barone, Matheus Villanueva Andrade, Rafael Ferreira Lima, Izabela Mamede, Clarisse Rezende Reis, Fernanda Martins Marim, Victor Emmanuel Viana Geddes, , Stevens Kastrup Rehen
This study shows that Oropouche virus strains cause microcephaly-like effects in brain organoids by disrupting neural development and inducing cell death and apoptosis.
bioRxiv · Aug 13, 2025 · PreprintNeuroscience