Kevin R Costello

This study identifies ZFP57 as a regulator of postnatal growth and lifelong health by influencing mammary gland function and lactation, with effects on offspring metabolic syndrome.

The paper analyzes young KRAB-zinc finger gene clusters in mice, showing ERVs drive genetic heterogeneity through recombination and duplication mechanisms.

The paper provides an allelic expression map of the mouse mammary gland across 10 developmental stages, identifying imprinted genes and their cell-type-specific expression patterns.

The paper presents T2T mouse genomes for C57BL/6J and CAST/EiJ, revealing structural diversity in telomeres, centromeres, and key loci like PAR and KZFPs.

This study shows that glucose-regulated O-GlcNAcylation of DNMT1 inhibits its methyltransferase activity, leading to epigenome changes and increased DNA damage.

The paper identifies sequence features of retrotransposons that influence epigenetic variability in DNA methylation, particularly in IAPs, by affecting KZFP and ZF-CxxC protein interactions.

This study shows that high fat diet-induced transcriptional responses in liver differ between rhesus macaques and mice, with species-specific regulatory elements driving these differences.

This study shows that Epstein-Barr virus transforms B cells to activate LTR enhancers and promoters, altering the transcriptome and impacting oncogenic processes.