Author

Candi Trac

City Of Hope National Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Approach:experimental assay· 5 Approach:statistical model· 5 Research Focus:gene regulatory network inference· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Assay:ATAC-seq· 2 Assay:DNA methylation· 2

Frequent Co-Authors

Dustin E. SchonesiD· 5 shared Amy LeungiD· 4 shared Kevin R CostelloiD· 3 shared Mudaser BasamiD· 2 shared Rama D NatarajaniD· 2 shared Aldons J. Lusis· 1 shared Anthony J. ParkiD· 1 shared Brian W. Parks· 1 shared

Activity by Year

2016-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersGenomics

Dustin E. SchonesORCID

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Author profile →

6 papers

Recent·Most cited

Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery

John Paul Murad, Lea Christian, Reginaldo Cruz Alves Rosa, Yuwei Ren, Eric Lee, Lupita S. Lopez, Anthony J. Park, Jason Yang, Candi Trac, Lauren N. Adkins, Wen‐Chung Chang, Catalina Martinez, Carl H. June, Stephen J. Forman, Jun Ishihara, , Saul J. Priceman

This study engineers CAR T cells with PDL1-IL12 fusion proteins to enhance anti-tumor responses in solid tumors by improving T cell function and reducing systemic inflammation.

bioRxiv · Apr 4, 2025 · PreprintBioengineering

Sequence features of retrotransposons allow for epigenetic variability

Kevin R Costello, Amy Leung, Candi Trac, Michael Lee, Mudaser Basam, John Andrew Pospisilik, Dustin E. Schones

The paper identifies sequence features of retrotransposons that influence epigenetic variability in DNA methylation, particularly in IAPs, by affecting KZFP and ZF-CxxC protein interactions.

eLife · Oct 20, 2021Peer-reviewedGenomics

Regulatory diversity contributes to a divergent transcriptional response to dietary changes in mammals

Kevin R Costello, Heon Shin, Candi Trac, Oleg Varlamov, Dustin E. Schones

This study shows that high fat diet-induced transcriptional responses in liver differ between rhesus macaques and mice, with species-specific regulatory elements driving these differences.

bioRxiv · Nov 1, 2020 · PreprintGenomics

Normal mammary epithelia accumulate DNA methylation changes with age that are consistent with breast cancer methylomes

Parijat Senapati, Masaru Miyano, Rosalyn W. Sayaman, Mudaser Basam, Candi Trac, Amy Leung, Mark A. LaBarge, Dustin E. Schones

This study identifies age-related DNA methylation changes in luminal mammary epithelial cells that correlate with breast cancer methylomes and contribute to lineage fidelity loss.

bioRxiv · Jun 26, 2020 · PreprintGenomics

LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptome

Amy Leung, Candi Trac, Hiroyuki Kato, Kevin R Costello, Zhaoxia Chen, Rama D Natarajan, Dustin E. Schones

This study shows that Epstein-Barr virus transforms B cells to activate LTR enhancers and promoters, altering the transcriptome and impacting oncogenic processes.

Genome Research · Dec 1, 2018Peer-reviewedGenomics

Chromatin variation associated with liver metabolism is mediated by transposable elements

Juan Du, Amy Leung, Candi Trac, Brian W. Parks, Aldons J. Lusis, Rama Natarajan, Dustin E. Schones

The paper identifies transposable elements (TEs) as contributors to chromatin accessibility variation in mice liver, linking TE polymorphism and DNA methylation to metabolic pathway differences.

bioRxiv · May 10, 2016Genomics