Author

Martin Mehnert

ETH ZurichORCID 0000-0001-7753-1596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ruedi H. AebersoldiD· 3 shared Federico UlianaiD· 2 shared Matthias GstaigeriD· 2 shared Rodolfo CiuffaiD· 2 shared Yansheng LiuiD· 2 shared Alessandro Ori‬‬iD· 1 shared Andrea FossatiiD· 1 shared Ari SatanowskiiD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersSystems Biology

Ruedi H. AebersoldORCID

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4 papers

Recent·Most cited

Systems BiologyProceedings of the National Academy of SciencesPeer-reviewedSep 30, 2022

Novel biochemical, structural and systems insights into inflammatory signaling revealed by contextual interaction proteomics

Rodolfo Ciuffa, Federico Uliana, Jonathan Mannion…·Ruedi H. Aebersold

The paper presents an integrated experimental and computational strategy to model protein-protein interactions in cellular context, applied to the TNF-receptor signaling complex.

17 citations

proteomicsexperimental assay

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Systems BiologybioRxivPreprintMar 13, 2022

Systematic dissection of phosphorylation-dependent YAP1 complex formation elucidates a key role for PTPN14 in Hippo signal integration

Federico Uliana, Rodolfo Ciuffa, Ranjan Kumar Mishra…·Matthias Gstaiger

The paper develops an experimental strategy to link phosphorylation events with protein complex formation, revealing PTPN14's role in regulating YAP1's interaction with LATS1/2 kinases.

1 citation

humanproteomics

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Systems BiologybioRxivPreprintDec 9, 2018

Rapid Proteomic Screen of CRISPR Experiment Outcome by Data Independent Acquisition Mass Spectrometry: A Case Study for HMGN1

Martin Mehnert, Wenxue Li, Chongde Wu…·Yansheng Liu

This study uses DIA-MS to rapidly assess proteomic changes after CRISPR-mediated HMGN1 knockout in cancer cells, identifying 147 significantly altered proteins and their functional impacts.

DOI 10.1101/490763

humanproteomics

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Systems BiologybioRxivPreprintApr 30, 2018

Genomic, Proteomic and Phenotypic Heterogeneity in HeLa Cells across Laboratories: Implications for Reproducibility of Research Results

Yansheng Liu, Mi Yang, Torsten Mueller…·Ruedi H. Aebersold

This study quantifies genomic, proteomic, and phenotypic variability in HeLa cells across laboratories and passages, revealing implications for research reproducibility.

8 citations

humanwhole-genome sequencing

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