Ari Satanowski

This paper evolves a halogenase enzyme to improve solubility and activity, enabling higher yields of halogenated compounds for sustainable bioproduction.

This paper combines adaptive laboratory evolution and machine learning to engineer a methylsuccinate module for synthetic C1 metabolism in E. coli, achieving growth in three weeks versus six months with evolution alone.

This paper demonstrates the efficient conversion of formate into methyl groups in engineered Escherichia coli using SAM-dependent methyltransferases, achieving over 70% formate-derived methyl groups.

This paper presents a computational workflow for designing and testing E. coli metabolic sensors that detect glyoxylate and glycolate across a wide concentration range, with applications in bioengineering and environmental monitoring.

The paper presents an integrated experimental and computational strategy to model protein-protein interactions in cellular context, applied to the TNF-receptor signaling complex.

This study identifies alternative glycolytic pathways in E. coli that bypass canonical EMP glycolysis, showing that the serine shunt is selected for in adaptive evolution.

This study identifies a new carbon fixation pathway in E. coli using only native enzymes and demonstrates its in vivo feasibility through genetic engineering.