Author

Eun Pyo Hong

Harvard UniversityORCID 0000-0001-7789-686XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Vanessa Chantal WheeleriD· 4 shared Alastair Maxwell· 3 shared Branduff McAllisteriD· 3 shared Darren G. MoncktoniD· 3 shared Diane E. LucenteiD· 3 shared G. Bernhard LandwehrmeyeriD· 3 shared Jacob M. LoupeiD· 3 shared James F. GusellaiD· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Vanessa Chantal WheelerORCID

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4 papers

Recent·Most cited

Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease

Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe, Vanessa Chantal Wheeler, Hannah E. Stutzman, Ben Kleinstiver, Jong‐Min Lee

The paper develops base editing strategies to convert CAG to CAA in Huntington's disease, reducing CAG repeat expansion and showing therapeutic potential.

eLife · Dec 19, 2023Peer-reviewedGenetics

FAN1 nuclease activity affects CAG expansion and age at onset of Huntington's disease

Branduff McAllister, Jasmine Donaldson, Caroline S. Binda, Sophie Powell, Uroosa Chughtai, Gareth Edwards, Joseph Stone, Sergey V. Lobanov, Linda Elliston, Laura-Nadine Schuhmacher, Elliott Rees, Georgina Elizabeth Menzies, Marc Ciosi, Alastair Maxwell, Michael J. Chao, , Thomas H. Massey

The paper identifies FAN1 nuclease activity as a modifier of CAG expansion and age at onset in Huntington's disease through exome sequencing and functional validation.

Nature Neuroscience · Apr 1, 2022Peer-reviewedNeuroscience

Genetic risk underlying psychiatric and cognitive symptoms in Huntington’s Disease

Natalie Ellis, Amelia Tee, Branduff McAllister, Thomas H. Massey, Duncan James McLauchlan, Timothy Stone, Kevin Correia, Jacob M. Loupe, Kyung‐Hee Kim, Douglas Barker, Eun Pyo Hong, Michael J. Chao, Jeffrey D. Long, Diane E. Lucente, Jean Paul Vonsattel, , Peter Holmans

The paper investigates genetic risk factors for psychiatric and cognitive symptoms in Huntington’s Disease using polygenic risk scores and finds associations between specific psychiatric risk scores and corresponding symptoms.

Biological Psychiatry · Dec 17, 2019Peer-reviewedGenetics

Huntington's disease onset is determined by length of uninterrupted CAG, not encoded polyglutamine, and is modified by DNA maintenance mechanisms

Jong‐Min Lee, Kevin Correia, Jacob M. Loupe, Kyung‐Hee Kim, Douglas Barker, Eun Pyo Hong, Michael J. Chao, Jeffrey D. Long, Diane E. Lucente, Jean‐Paul Vonsattel, Ricardo Mouro Pinto, Kawther Abu Elneel, Eliana Marisa Ramos, Jayalakshmi Srinidhi Mysore, Tammy Gillis, , Richard H. Myers

This study shows that the length of uninterrupted CAG repeats, not the encoded polyglutamine segment, determines Huntington's disease onset, and DNA maintenance genes modify this process.

bioRxiv · Jan 24, 2019 · PreprintGenetics