Author

Uroosa Chughtai

University of OxfordORCID 0000-0001-8110-7114Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Brent James RyaniD· 2 shared Janine BrandesiD· 2 shared Maria Claudia CaiazzaiD· 2 shared Ricardo Márquez-GómeziD· 2 shared Richard Wade‐MartinsiD· 2 shared William McGuinnessiD· 2 shared Alastair Maxwell· 1 shared Albert KoulmaniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Brent James RyanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 1, 2026

Phenotypic screening in Parkinson's iPSC-dopamine neurons identifies the FASN-SREBP1 axis as a potential therapeutic target

Maria Claudia Caiazza, Janine Brandes, Elizabeth R. Barrow…·Richard Wade‐Martins

The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.

DOI 10.64898/2026.10.27.761977

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceCell ReportsPeer-reviewedMar 1, 2023

A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons

Helle Bogetofte, Brent James Ryan, Pia Jensen…·Richard Wade‐Martins

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

47 citationstop 1%

humanproteomics

𝕏 PostBluesky

NeuroscienceNature NeurosciencePeer-reviewedApr 1, 2022

FAN1 nuclease activity affects CAG expansion and age at onset of Huntington's disease

Branduff McAllister, Jasmine Donaldson, Caroline S. Binda…·Thomas H. Massey

The paper identifies FAN1 nuclease activity as a modifier of CAG expansion and age at onset in Huntington's disease through exome sequencing and functional validation.

89 citationstop 1%

humanwhole-exome sequencing

𝕏 PostBluesky