Atsushi Saito

This study identifies the role of anterior insular cortex neurons in higher-order threat learning and memory, showing they are essential for temporally separated or diffuse threat contexts but constrain fear expression during retrieval.

The paper maps R-loop landscapes in the developing human brain and shows their role in neural differentiation and gene expression programs.

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

This study identifies the role of CMV viral protein IE1 in disrupting host DISC1-PML interaction, leading to neural progenitor deficits in congenital CMV infection.

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

This study shows that brain-synthesized estrogens affect cortical neuron migration differently in male and female mice through Cyp19a1 knockdown.

The paper shows that epigenetic editing of the Sema6a promoter can reverse impaired transcallosal connectivity caused by C11orf46 mutations.