Philippa Melamed

The paper shows DNA-bound Egr-1 delays RNA polymerase elongation through kinetic destabilization, with CpG methylation reducing this delay.

The paper shows that most gonadotrophs in adults originate from postnatal pituitary stem cells during minipuberty, while embryonic gonadotrophs are maintained, revealing a dual origin.

This study compares epigenetic age and methylation stability between British-Bangladeshi women who grew up in Bangladesh versus the UK, finding older epigenetic age and more stable methylation in those from Bangladesh.

The paper identifies epigenetic regulation of SRD5A1 as a mechanism linking early-life environment to reproductive strategies, showing methylation patterns and gene expression changes in both humans and mice.