Author

Sergei Rudnizky

Boston Children's HospitalORCID 0000-0002-0520-0752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Ariel KaplaniD· 3 shared Taekjip HaiD· 3 shared Emily Winther SørenseniD· 2 shared Iain F. DavidsoniD· 2 shared Jan‐Michael PetersiD· 2 shared Laura CaccianiniiD· 2 shared Lucas FarnungiD· 2 shared Manuel Osorio‐ValerianoiD· 2 shared

Activity by Year

2017-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiophysics

Ariel KaplanORCID

Author profile →

6 papers

Recent·Most cited

A Distributed Architectural Code Governs DNA Repair

Anisha K. Hundal, Defne Urman, Araad Algouneh, Rehna Krishnan, Chris A. Jordan, Sergei Rudnizky, Adam T Rybczynski, Tamari Chkuaseli, Anne Hakem, Jun Hao, Philipp G. Maass, Taekjip Ha, Razq Hakem, Karim Mekhail

The paper identifies a distributed architectural code involving cytoskeletal, membrane, and lipid regulators that governs nuclear reshaping during DNA repair.

bioRxiv · Oct 19, 2026 · PreprintMolecular Biology

Tunable kinetic destabilization governs RNA polymerase passage through a DNA-bound transcription factor

Noam Nago, Sergei Rudnizky, Nir Strugo, Moshe Goldsmith, Carmit Burstein, Philippa Melamed, Ariel Kaplan

The paper shows DNA-bound Egr-1 delays RNA polymerase elongation through kinetic destabilization, with CpG methylation reducing this delay.

bioRxiv · Jul 30, 2026 · PreprintBiophysics

A Modular Framework for Automated Segmentation and Analysis of AFM Imaging of Chromatin Organization

Emily Winther Sørensen, Sushil Pangeni, Raquel Merino‐Urteaga, Peter J. Murray, Sergei Rudnizky, T S Liao, Fahad Rashid, Jihee Hwang, Maryam Yamadi, Xinyu Ashlee Feng, Jonas Zähringer, Stephanie Gu, Iain F. Davidson, Laura Caccianini, Manuel Osorio‐Valeriano, , Taekjip Ha

DNAsight automates AFM image analysis of chromatin organization, revealing protein-specific structural signatures and nucleosome spacing distributions.

Nucleic Acids Research · Jun 10, 2026Peer-reviewedBiophysics

Chromatin boundary permeability is controlled by CTCF conformational ensembles

Sergei Rudnizky, Peter J Murray, Emily Winther Sørensen, Theo J. R. Koenig, Sushil Pangeni, Raquel Merino‐Urteaga, Hemani Chhabra, Laura Caccianini, Iain F. Davidson, Manuel Osorio‐Valeriano, Paul W. Hook, Paul Meneses, Jingzhou Hao, Jasmin S. Zarb, Nikos S. Hatzakis, , Taekjip Ha

The paper shows CTCF controls chromatin boundary permeability through a dynamic conformational ensemble, not static occupancy, influencing cohesin capture probabilities.

bioRxiv · Nov 25, 2025 · PreprintBiophysics

Auxiliary ATP binding sites power rapid unwinding by RecBCD

Rani Zananiri, Vera Gaydar, Dan Yahalom, Omri Malik, Sergei Rudnizky, Ariel Kaplan, Arnon Henn

This study identifies auxiliary ATP binding sites in RecBCD that modulate its unwinding rate by affecting ATP flux to catalytic sites.

bioRxiv · Mar 22, 2018 · PreprintBiophysics

Mobile nucleosomes and the accessibility of transcription factors to DNA: a modified dynamic equilibrium model

Hadeel Khamis, Sergei Rudnizky, Ariel Kaplan

The paper presents a dynamic equilibrium model to quantify how nucleosome mobility affects transcription factor DNA accessibility.

bioRxiv · Sep 12, 2017 · PreprintBiophysics