Paola Bovolenta

Pharmacodynamic and stage-dependent therapeutic efficacy of SFRP1 neutralization in a mouse model of Alzheimer s disease

This study evaluates the therapeutic efficacy of SFRP1 neutralization at different disease stages in a mouse model of Alzheimer's disease, finding that early intervention is most effective.

SFRP1 drives glycolytic activation in astrocytes during neuroinflammation

This study shows SFRP1 drives astrocytic glycolytic activation during neuroinflammation, enhancing metabolic flexibility to meet energy demands.

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.

Foxd1 dependent induction of temporal retinal character is required for visual function

This study shows that Foxd1 is required for temporal retinal character, which is essential for the development of the high acuity area and visual function in zebrafish.

SFRP1 shapes astrocyte to microglia cross-talk in acute and chronic neuroinflammation

This study shows that SFRP1 from astrocytes promotes microglial activation in acute and chronic neuroinflammation, suggesting it as a therapeutic target.

Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis

This study shows that zebrafish RPE cells stretch to match retinal curvature during optic cup formation, with proliferation and cytoskeletal interference affecting this process.

Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish

The paper analyzes gene network bifurcation during optic cup morphogenesis in zebrafish, identifying regulatory mechanisms and conserved TF recruitment sequences in RPE specification.

Maternal vgll4a promotes blastoderm cohesion enabling yap1-mediated mechano-transduction during zebrafish epiboly

This study shows that maternal vgll4a coordinates blastomere adhesion and cohesion during zebrafish epiboly, enabling Yap1-mediated mechano-transduction.

Sfrp1 deficiency makes retinal photoreceptors prone to degeneration

This study shows that Sfrp1 deficiency leads to photoreceptor degeneration and increased light-induced damage in mice, highlighting SFRP1's role in maintaining outer limiting membrane integrity.