A low-androgen environment sustains redox-active sGC states required to restrain castration-resistant prostate cancer growth via elevated cGMP levels
Clara I. Troccoli, Beatriz Mateo-Victoriano, Annie V. Beuve, Mercè Jordà, Janaki Neela Sharma, Priyamvada Rai
This study shows that a low-androgen environment maintains redox-active sGC states, enhancing riociguat efficacy in castration-resistant prostate cancer by increasing cGMP levels.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology