Raghavi Sudharsan

Ultrastructure expansion microscopy of dog, macaque and human retinas shows conserved rod-cone differences in the photoreceptor ciliary core but species-divergent periciliary membranes, calyceal processes and rootlets.

This study uses ultrastructure expansion microscopy to map protein distribution in canine photoreceptor sensory cilia and calyceal processes, revealing architectural differences between rods and cones.

This paper demonstrates that gene therapy using AAV-mediated NPHP5 augmentation restores photoreceptor structure and function in a canine model of Leber congenital amaurosis.