William A. Beltran

Cross-species molecular mapping of the photoreceptor sensory cilium and periciliary structures identifies conserved and species-specific architectural features

Ultrastructure expansion microscopy of dog, macaque and human retinas shows conserved rod-cone differences in the photoreceptor ciliary core but species-divergent periciliary membranes, calyceal processes and rootlets.

Mapping protein distribution in the canine photoreceptor sensory cilium and calyceal processes by ultrastructure expansion microscopy

This study uses ultrastructure expansion microscopy to map protein distribution in canine photoreceptor sensory cilia and calyceal processes, revealing architectural differences between rods and cones.

Cone-driven, geniculo-cortical responses in canine models of outer retinal disease

The paper uses fMRI to assess cone-driven responses in canine retinal disease models, finding preserved responses in some models and restored function in NPHP5-CRD2 after gene augmentation.

Targeting ON-bipolar cells by AAV gene therapy stably reverses LRIT3-congenital stationary night blindness

This paper demonstrates that AAV gene therapy targeting ON-bipolar cells in a canine model of LRIT3-CSNB significantly improves night vision and restores LRIT3 function.

Gene Therapy Reforms Photoreceptor Structure and Restores Vision in NPHP5-associated Leber Congenital Amaurosis

This paper demonstrates that gene therapy using AAV-mediated NPHP5 augmentation restores photoreceptor structure and function in a canine model of Leber congenital amaurosis.