Andrew F. Stewart

This paper shows harmine, a DYRK1A inhibitor, selectively promotes human beta cell differentiation and function via PKA activation, distinct from other DYRK1A inhibitors.

This study shows that nutrient excess remodels pancreatic islet innervation through Schwann cells, impairing glycemic control, and demonstrates that neuromodulation can improve outcomes.

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

This study identifies β cell-specific lncRNAs that regulate transcriptional networks and show dysregulation in type 2 diabetes.