ImmunologybioRxivPreprint
NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection
Zahrasadat Navaeiseddighi, Zhihan Wang, Kai Guo…·M. Nadeem Khan
This study shows that influenza co-infection disrupts epithelial tolerance to Streptococcus pneumoniae via NF-κB driven inflammation, leading to bacterial invasion and highlighting TRAF6-NF-κB as a therapeutic target.