Author

Andrés López‐Perrote

Spanish National Cancer Research CentreORCID 0000-0001-7872-3442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Óscar LlorcaiD· 2 shared Alberto Palacios‐AbellaiD· 1 shared Carlos Chacón-SáncheziD· 1 shared Clara RegleroiD· 1 shared Cristina ÚrbeziD· 1 shared David AlabadíiD· 1 shared Elena Blanco‐RomeroiD· 1 shared Ester Casajús-PelegayiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Óscar LlorcaORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 28, 2026

Disruption of R2TP-mediated PIKK maturation with de novo designed binders

Nayim González-Rodríguez, Andrés López‐Perrote, Clara Reglero…·Rafael Fernández-Leiro

The paper identifies RUVBL1/2-RPAP3 interface as a vulnerability and develops de novo protein binders that selectively disrupt R2TP, reducing PIKK levels without affecting other RUVBL1/2 complexes.

DOI 10.64898/2026.10.26.761954

experimental assay

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BiochemistryStructurePeer-reviewedFeb 26, 2025

The structure of the R2T complex reveals a different architecture of the related HSP90 co-chaperones R2T and R2TP

Alberto Palacios‐Abella, Andrés López‐Perrote, Jasminka Boskovic…·David Alabadí

The paper determines the cryoEM structure of the Arabidopsis R2T complex, revealing its dodecameric organization and distinct architecture compared to the human R2TP complex.

11 citations

Arabidopsiscryo-EM

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