Óscar Llorca

Disruption of R2TP-mediated PIKK maturation with de novo designed binders

The paper identifies RUVBL1/2-RPAP3 interface as a vulnerability and develops de novo protein binders that selectively disrupt R2TP, reducing PIKK levels without affecting other RUVBL1/2 complexes.

OT-Curtains: an approach for studying protein interactions with DNA-ends using optical tweezers and confocal fluorescence microscopy

OT-Curtains enables real-time observation of DNA-end interactions using optical tweezers and microscopy, demonstrating applications in DNA repair and telomere biology.

Automated and modular protein binder design with BinderFlow

This paper introduces BinderFlow, a modular pipeline for protein binder design, and BFmonitor, a dashboard for campaign monitoring, making generative protein design more accessible.

The structure of the R2T complex reveals a different architecture of the related HSP90 co-chaperones R2T and R2TP

The paper determines the cryoEM structure of the Arabidopsis R2T complex, revealing its dodecameric organization and distinct architecture compared to the human R2TP complex.

Conserved Lysine in transmembrane helix 5 is key for the inner gating of the LAT transporter BasC

This study identifies a conserved lysine in TM5 of BasC as critical for cytoplasmic gate dynamics, showing its role in gating transitions and modulation by substrates and mutations.

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.