Matthias Bochtler

This study identifies Csx15 as a ring nuclease that degrades cyclic nucleotides from both CRISPR-Cas and CBASS systems, revealing its role in regulating signaling pathways.

The paper identifies new prokaryotic wH domain-containing endonucleases that sense adenine methylation in specific DNA contexts.

The paper shows that PHD domains in KMT2/MLL proteins bind to H3K4me3 and acetylated promoters/enhancers, with CXXC domains influencing promoter preference and mutations affecting function.

The paper identifies sequence preferences of TET enzymes that target DNA demethylation to bHLH and bZIP transcription factor binding sites.

This study shows that Adar-mediated A-to-I editing is essential for establishing antero-posterior and dorso-ventral axes in zebrafish embryos.

This study demonstrates that CRISPR endoribonucleases can efficiently knock down mRNA transcripts in zebrafish, with varying effectiveness across different EGFP-expressing lines.