Katarzyna Misztal

Phosphorylation of the AP2 μ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis.

This study identifies that phosphorylation of AP2 μ2 subunit by p70S6 kinase modulates its conformational dynamics, enhancing clathrin-mediated endocytosis of receptors.

Enhancer-mediated metabolic pre-patterning defines trabecular cardiomyocyte identity prior to morphogenesis

The paper identifies an enhancer, -6.8got2b, critical for trabecular cardiomyocyte development in zebrafish and shows its conservation and function in humans.

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers

The paper shows that PHD domains in KMT2/MLL proteins bind to H3K4me3 and acetylated promoters/enhancers, with CXXC domains influencing promoter preference and mutations affecting function.

Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function

The paper identifies sequence preferences of TET enzymes that target DNA demethylation to bHLH and bZIP transcription factor binding sites.

Adar-mediated A-to-I editing is required for establishment of embryonic body axes in zebrafish

This study shows that Adar-mediated A-to-I editing is essential for establishing antero-posterior and dorso-ventral axes in zebrafish embryos.