Xinyue Liu

This study shows that the catalytic pocket of Clr4 (Suv39h) acts as a receptor for Cul4-dependent H3K14 ubiquitination, which regulates Clr4's methylation activity on H3K9.

The paper systematically explores human genome target spaces for protein and peptide drugs, identifying distinct characteristics and developing genome-wide target estimation models for each.

SeqEnhDL classifies cell type-specific enhancers using deep learning, outperforming existing methods and directly distinguishing enhancers from different cell types.