Danesh Moazed

This study shows genetic compensation in ACTB mutants occurs via SRF/MRTF-A transcriptional feedback, independent of mutant mRNA expression or degradation.

This study identifies factors required for establishing and maintaining mammalian heterochromatin, showing that DHX9 and H3K9me erasers influence its stability during differentiation.

This study shows that the catalytic pocket of Clr4 (Suv39h) acts as a receptor for Cul4-dependent H3K14 ubiquitination, which regulates Clr4's methylation activity on H3K9.

This paper demonstrates a simple mechanism for sequence-independent silent chromatin inheritance in yeast using two interdependent proteins.

The paper shows that Polycomb silencing at developmental genes is heritable through specific sequence and epigenetic mechanisms, while silencing at housekeeping genes is not.

The paper identifies the rixosome, an RNA degradation complex, as essential for heterochromatin spreading and epigenetic inheritance by degrading heterochromatic RNAs.

The paper shows the rixosome, an RNA degradation complex, associates with human PRC complexes and is required for silencing Polycomb target genes.