Catalytic pocket of Clr4 (Suv39h) methyltransfer-ase serves as a substrate receptor for Cullin 4-dependent histone H3 ubiquitination
Katarína Pšenáková, Swapnil S. Parhad, João A. Paulo, Xinyue Liu, Emily F. Patterson, Rachel Watson, Marcus Adrian Cheek, Michael‐Christopher Keogh, Marian Kalocsay, Steven P. Gygi, Lucas Farnung, Danesh Moazed
This study shows that the catalytic pocket of Clr4 (Suv39h) acts as a receptor for Cul4-dependent H3K14 ubiquitination, which regulates Clr4's methylation activity on H3K9.
bioRxiv · Aug 28, 2025 · PreprintBiochemistry