Author

Dongwen Wu

Cornell UniversityORCID 0000-0001-7909-5708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander E. Brady· 1 shared Alexandria Lydecker· 1 shared Brian D. RuddiD· 1 shared Elliott J. Purser· 1 shared Hannah Fisk· 1 shared Khadija Kone· 1 shared Mandy J. McGeachyiD· 1 shared Norah L. SmithiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alexander E. Brady

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintMar 10, 2025

Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors

Alexander E. Brady, Shankar K. Revu, Dongwen Wu…·Mandy J. McGeachy

A single amino acid substitution in CD28 enhances signaling, leading to increased CD8 activation and Tpex generation during viral infection, while accelerating exhaustion in chronic infection.

DOI 10.1101/2025.03.10.642460

mouseexperimental assay