Norah L. Smith

Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors

A single amino acid substitution in CD28 enhances signaling, leading to increased CD8 activation and Tpex generation during viral infection, while accelerating exhaustion in chronic infection.

Single-cell multiomics reveals the distinct properties of neonatal and adult recent thymic emigrants

This study compares neonatal and adult CD8+ recent thymic emigrants using single-cell multiomics, finding distinct phenotypes and functions despite similar post-thymic maturation.

Recent thymic emigrants are preferentially recruited into the memory pool during persistent infection

This study shows that recent thymic emigrants are preferentially recruited into the memory pool during persistent CMV infection, while mature CD8+ T cells contribute little.

Deciphering gene regulatory programs underlying functionally divergent naive T cell subsets

The paper identifies gene regulatory programs distinguishing naive CD8+ T cell subsets using RNA-seq and ATAC-seq data, revealing novel regulators and transcriptional networks.