Chantal Dessy

Beige/brown fat-mediated cardiac protection from high-fat diet is dependent on adipocyte beta3-adrenergic receptor

This study shows that adipocyte beta3-adrenergic receptor activation protects against high-fat diet-induced cardiac damage by promoting beige fat formation and adipose-cardiac communication.

Acidosis-triggered fatty acid overload induces endothelial cell dysfunction.

This study shows acidosis enhances fatty acid uptake in endothelial cells, leading to lipid droplet formation, ER stress, and reduced nitric oxide, contributing to endothelial dysfunction.

Hepatic ADMA/PRMT1 axis regulation is associated with NO-dependent endothelial dysfunction in MASH

This study investigates how MASH impairs endothelial function via NO-dependent mechanisms and identifies ADMA as a key liver-derived mediator.

When the liver is in poor condition, so is the heart - cardiac remodelling in MASH mouse models

This study examines cardiac remodelling in MASH mouse models, finding adverse structural changes in the heart linked to liver disease, not overfeeding or aging.

A matter of food and substrain: obesogenic diets induce differential severity of cardiac remodeling and diastolic dysfunction in C57Bl/6J and C57Bl/6N substrains

This study compares cardiac remodeling and diastolic dysfunction in C57Bl/6J and C57Bl/6N mice on obesogenic diets, finding strain-specific responses to diet.