Author

Stephan Emmrich

University of RochesterORCID 0000-0002-0537-4242Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Vera A. GorbunovaiD· 4 shared Andrei SeluanoviD· 3 shared Amin HaghaniiD· 2 shared Caesar Z. LiiD· 2 shared Chris G. FaulkesiD· 2 shared Joseph Alan ZolleriD· 2 shared Joshua ZhangiD· 2 shared Julia AblaevaiD· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersDevelopmental Biology

Vera A. GorbunovaORCID

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4 papers

Recent·Most cited

Developmental BiologyNature AgingPeer-reviewedAug 10, 2023

Universal DNA methylation age across mammalian tissues

Ake Tzu-Hui Lu, Zhe Fei, Amin Haghani…·June Mergl

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

396 citationstop 1%

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Molecular BiologyThe EMBO JournalPeer-reviewedOct 10, 2022

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Matthew A. Simon, Jiping Yang, Jonathan Gigas…·Vera A. Gorbunova

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

73 citationstop 1%

humanDNA methylation

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Developmental BiologybioRxivPreprintAug 1, 2021

An abundant myeloid progenitor shapes neonatal hematopoiesis of naked mole-rats

Stephan Emmrich, Alexandre Trapp, Andrei Seluanov, Vera Gorbunova

The paper identifies a unique myeloid progenitor cell type, TC90, specific to neonatal naked mole-rats that supports innate immunity during early development.

1 citation

bulk RNA-seqstatistical model

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Developmental BiologybioRxivPreprintMar 15, 2021

DNA methylation clocks show slower progression of aging in naked mole-rat queens

Steve Horvath, Amin Haghani, Nicholas Macoretta…·Vera Gorbunova

This study develops DNA methylation clocks for naked mole-rats and finds that queens age more slowly than non-breeders, suggesting a link between reproductive status and epigenetic aging.

9 citations

DNA methylationstatistical model

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