Samuel Origlio

The paper shows that IgE memory responses are confined to lymphoid organs through GC IL-4 microniches, which are critical for IgE production during allergen recall.

The paper shows that mucosal B cell memory selection diverges between lungs and gut, favoring MBCs and PCs respectively, driven by tissue-specific BCR isotype usage rather than affinity.

The paper tracks GC-derived B cells in lymph nodes to identify PrePC cells and their transition to plasma cells, revealing spatial and transcriptional changes during differentiation.