Author

Jack P. C. Williams

The Francis Crick InstituteORCID 0000-0002-6239-9083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Louise J. WalportiD· 2 shared M. Teresa BertraniD· 2 shared Afshan McCarthyiD· 1 shared Anne WestoniD· 1 shared Daniel R. Leonce· 1 shared James M. A. TurneriD· 1 shared Jessica OlseniD· 1 shared Joseph A. MarshiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersDevelopmental Biology

Louise J. WalportORCID

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2 papers

Recent·Most cited

Dissecting PADI6 function defines oocyte cytoplasmic lattices as regulatory hubs for fundamental cellular processes

Jack P. C. Williams, Tania Auchynnikava, Afshan McCarthy, M. Teresa Bertran, Obah A. Ojarikre, Anne Weston, Daniel R. Leonce, Jessica Olsen, Kathy K. Niakan, Mark J. Skehel, James M. A. Turner, Louise J. Walport

The paper investigates PADI6's role in oocyte cytoplasmic lattices using single-cell proteomics and transcriptomics, revealing its critical scaffolding function and connections to other oocyte compartments.

bioRxiv · Feb 21, 2025 · PreprintDevelopmental Biology

Structural Insight into the Function of Human Peptidyl Arginine Deiminase 6

Jack P. C. Williams, Stéphane Mouilleron, Rolando Hernández Trapero, M. Teresa Bertran, Joseph A. Marsh, Louise J. Walport

This study determines the crystal structure of human PADI6, revealing structural differences that suggest it lacks catalytic activity compared to other PADIs.

Computational and Structural Biotechnology Journal · Aug 16, 2024Peer-reviewedBiochemistry