Multimodal analysis of osteoarthritic chondrocytes reveals mitochondrial alterations and patient-specific OxPhos response to bezafibrate
Lucie Danet, Romain Guiho, Sally Hussein, A. Defois, Nicolas Gaigeard, Joëlle Véziers, Guillaume Mabilleau, Antoine Hamel, Denis Waast, Jérôme Guicheux, Marie‐Astrid Boutet, Claire S. Vinatier
This study identifies mitochondrial alterations in osteoarthritic chondrocytes and shows that bezafibrate improves OxPhos function in a subset of patients.
bioRxiv · Oct 28, 2025 · PreprintPathology