Yasmine Cantaut-Belarif

This study identifies astrogliosis and neuroinflammation as pathogenic mechanisms underlying scoliosis in zebrafish caused by cilia dysfunction.

This study generates Sspo knockout mice and finds reduced brain ventricle size but only minor spine curvature defects.

The paper shows the Reissner fiber regulates CSF-cNs via urp2 and calcium signaling, and adrenergic activation can substitute its function in zebrafish embryos.

The paper shows that Reissner fiber is critical for CSF-contacting neurons to detect spinal curvature in zebrafish larvae.

This study identifies Pkd2l1 as essential for mechanosensation in cerebrospinal fluid-contacting neurons and spine curvature maintenance in zebrafish.