Stelios Papadopoulos

NEURD automates proofreading and feature extraction from connectomics data to improve accuracy and accessibility of neural morphology analyses.

The paper presents a functional connectomics dataset of mouse visual cortex, combining calcium imaging with EM reconstruction to study neural circuits and their connectivity.

Functionally similar neurons in mouse visual cortex connect preferentially across layers and areas, including feedback, and feature tuning, not receptive-field position, predicts synapses beyond axon-dendrite proximity.

The paper uses graph-based machine learning to analyze dendritic morphology of excitatory neurons in mouse visual cortex, finding a continuous morphological landscape rather than discrete types.

This paper trains a foundation model on neural activity data to predict responses to new stimuli and anatomical features, showing strong generalization across mice and tasks.

The paper identifies a novel bipartite invariance in mouse V1 neurons, where receptive fields encode shift-invariant high-frequency textures and fixed low-frequency patterns, contributing to segmentation.

The paper uses CNNs to analyze contextual modulation in visual cortex by synthesizing surround patterns, finding that pattern completion enhances responses while disruption suppresses them, consistent across mice and macaques.

Cloud-run convolutional nets aligned 19,939 serial EM sections of mouse visual cortex despite cracks and folds, segmented neurons and detected 523 million synapses; code and the reconstruction are public.

The paper characterizes cell types and circuit organization within neocortical radial clones using single-cell RNA-sequencing and electrophysiological recordings, finding that clones contain diverse cell types and exhibit specific connectivity patterns.

The paper identifies distinct cell types and circuit organization in layer 4 of primary sensory areas in adult mouse neocortex, challenging the canonical microcircuit model.