Ran Lu

The paper presents the first densely reconstructed adult fruit fly connectome integrating the brain and ventral nerve cord, revealing distributed control circuits involving local and long-range neural connections.

Eyewire II provides a large-scale EM dataset of the mouse retina, enabling cell type annotation and connectivity mapping through human-in-the-loop deep learning and functional alignment.

The paper maps large-scale neuronal connections in mouse hippocampal CA3, revealing spatially graded mossy fiber inputs and a feedforward inhibitory circuit targeting specific pyramidal cells.

CAVE enables reproducible connectome analysis in large-scale datasets during ongoing annotation and proofreading.

NEURD automates proofreading and feature extraction from connectomics data to improve accuracy and accessibility of neural morphology analyses.

The paper presents a functional connectomics dataset of mouse visual cortex, combining calcium imaging with EM reconstruction to study neural circuits and their connectivity.

Functionally similar neurons in mouse visual cortex connect preferentially across layers and areas, including feedback, and feature tuning, not receptive-field position, predicts synapses beyond axon-dendrite proximity.

The paper uses graph-based machine learning to analyze dendritic morphology of excitatory neurons in mouse visual cortex, finding a continuous morphological landscape rather than discrete types.

The paper presents a connectome of the human foveal retina using deep learning, revealing novel synaptic pathways and distinct neural circuits unique to humans.

The paper presents the first neuronal wiring diagram of a whole adult Drosophila brain, revealing synaptic connections and circuit mechanisms underlying sensorimotor behaviors.

This paper improves TEM imaging speed by using beam deflection to capture multiple image tiles, increasing efficiency for millimeter-scale brain tissue imaging.

The paper reconstructs and analyzes the female Drosophila ventral nerve cord connectome, identifying neural circuits that coordinate wings and legs during escape takeoff.

The paper analyzes premotor circuits in Drosophila to compare leg and wing motor control networks, finding modular organization and differences in synaptic connectivity.

The paper investigates the synaptic connectivity of thick tufted layer 5 pyramidal neurons in the mouse visual cortex, revealing their local inhibitory and long-range excitatory connections.

Electron microscopy of 1352 neurons in a mouse visual cortex column reveals widespread cell-type-specific inhibition, a basket-cell-targeting disinhibitory class, and interneuron motif groups sharing excitatory targets.

The paper maps synaptic connectivity between cortical pyramidal neurons and shows synapse size is modeled by a combination of binary and analog variables.

The paper uses electron microscopy data to classify cell types in the neocortex based on perisomatic features, showing that these features are sufficient for accurate classification even in large datasets.

FlyWire enables collaborative proofreading of whole-brain connectomes through an online platform, demonstrating its utility in reconstructing and analyzing mechanosensory neuron circuits.

Cloud-run convolutional nets aligned 19,939 serial EM sections of mouse visual cortex despite cracks and folds, segmented neurons and detected 523 million synapses; code and the reconstruction are public.

The paper identifies oligodendrocyte precursor cells (OPCs) as major contributors to axon pruning in the mouse neocortex through phagocytic activity.

This study identifies pC1-Alpha neurons in Drosophila females that drive persistent behaviors through recurrent neural connectivity.

The paper presents a semi-automated reconstruction of mouse primary visual cortex from electron microscopy data, revealing structural and functional relationships in cortical circuits.

The paper maps chandelier cell synapses onto pyramidal neurons and finds variability in synaptic input correlated with target neuron features, while showing functional correlation with arousal state.

The paper introduces EASE, a method that matches calcium imaging signals to EM-derived cell segments in mouse visual cortex, enabling dendritic functional analysis and denoising.