Author

Carlos Guijas

ORCID 0000-0001-7993-3388Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Dylan M. Herbst· 2 shared Taylor Andalis· 2 shared Aishwarya C. Ballapuram· 1 shared Benjamin F. CravattiD· 1 shared Benjamin J. HuangiD· 1 shared Boer Xie· 1 shared Camille J. Leung· 1 shared Cassandra L. Henry· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersNeuroscience

Dylan M. Herbst

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 22, 2025

Base exchange inhibitors of SARM1 form mononucleotide adducts and activate SARM1 in vivo

Holly T. Reardon, Carlos Guijas, Jason R. Clapper…·Tarek A. Samad

The paper shows that SARM1 base exchange inhibitors form mononucleotide adducts and paradoxically activate SARM1, leading to increased cADPR and cADPR/NAD ratios in vivo.

4 citations

mousehuman

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Cancer BiologybioRxivPreprintMar 20, 2025

In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

Matthew Decker, Benjamin J. Huang, Timothy B. Ware…·Kevin Shannon

This study validates the palmitoylation cycle as a therapeutic target in NRAS-mutant cancers by showing that inhibiting ABHD17 reduces tumor growth and synergizes with MEK inhibitors.

3 citations

mouseexperimental assay

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