Pharmacology & ToxicologybioRxivPreprint
Evaluation of Retinal Safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors
Junki Hoshino, Kazuki Irie, Akimitsu Konishi…·Yoji Andrew Minamishima
This study evaluates the effects of five HIF-PH inhibitors on Vegfa expression in the retina and other tissues of mice, finding differential regulation across tissues and suggesting retinal VEGF upregulation as a safety concern.
DOI 10.64898/2026.06.29.735161