Linda K. Hanley-Bowdoin

This study identifies plant host factors involved in geminiviral DNA replication using proximity labeling and functional assays, revealing the selective repurposing of eukaryotic replication machinery.

The paper uses Hi-C and 3D FISH to show maize euchromatin has two distinct interphase subcompartments, early-S and middle-S, defined by replication timing and chromatin organization.

This study shows that geminivirus TYLCV uses alternative splicing to generate Rep isoforms with distinct functions in viral replication and gene regulation.

The paper develops a modular geminivirus-based vector system for improved protein expression and gene targeting in plants, showing that native promoters and removal of virion-sense genes enhance reporter expression without affecting replicon accumulation.

The paper investigates how SEGS-1 episomes affect cassava mosaic disease severity in different cassava cultivars, showing cultivar-dependent effects and identifying functional regions of SEGS-1.

The paper compares DNA replication timing in mitotic and endocycling cells in maize roots, finding significant shifts in centromere replication timing during the endocycle.

Repliscan classifies replication timing regions from Repli-seq data by normalizing, filtering, and assigning replication signatures, outperforming previous methods with variable thresholds.