Heng Yang Lee

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

The paper identifies SALL4 as a protein that interprets DNA base composition by binding to AT-rich motifs, and shows its role in controlling cell fate through regulation of AT-rich gene expression.