Author

Francesca Taglini

Edinburgh Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 2 Biochemistry· 1 Genomics· 1 Molecular Biology· 1

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Research Focus:differential expression· 4 Organism:human· 4 Assay:DNA methylation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Duncan SprouliD· 4 shared Hazel Davidson‐Smith· 3 shared Ioannis KafetzopoulosiD· 3 shared Cristina Rubio-Ramon· 2 shared Hannah FinaniD· 2 shared Hannah WapenaariD· 2 shared Jimi C. WillsiD· 2 shared Kamila Irena MusialikiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Duncan SproulORCID

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Author profile →

5 papers

Recent·Most cited

Disease mutations in the PWWP domain of DNMT3A affect chromatin recruitment through multiple mechanisms

Hannah Wapenaar, Gillian Clifford, Francesca Taglini, Finlay McGhie, Willow Rolls, Yujie Zhang, Duncan Sproul, Marcus D. Wilson

This study examines how mutations in the PWWP domain of DNMT3A affect chromatin recruitment through different mechanisms, leading to distinct disease phenotypes.

bioRxiv · Aug 31, 2026 · PreprintBiochemistry

DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A

Ioannis Kafetzopoulos, Francesca Taglini, Moira Pasquier, Hazel Davidson‐Smith, Christine J. Rodger, Lucia Puchades Gimeno, Andrew A. Malcolm, Duncan Sproul

This study shows that DNMT1 loss causes hypomethylation in late replicating domains but also leads to hypermethylation in some domains due to DNMT3A activity, altering chromatin states.

PLoS Genetics · Apr 2, 2026Peer-reviewedGenomics

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

Francesca Taglini, Ioannis Kafetzopoulos, Willow Rolls, Kamila Irena Musialik, Heng Yang Lee, Yujie Zhang, Mattia Marenda, Lyndsay Kerr, Hannah Finan, Cristina Rubio-Ramon, Philippe Emmanuel Gautier, Hannah Wapenaar, Dhananjay Kumar, Hazel Davidson‐Smith, Jimi C. Wills, , Duncan Sproul

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

EMBO Reports · Jan 30, 2024Peer-reviewedGenetics

Separable roles for RNAi in regulation of transposable elements and viability in the fission yeast Schizosaccharomyces japonicus

Elliott Chapman, Francesca Taglini, Elizabeth H. Bayne

The paper investigates RNAi's role in transposable element suppression and viability in S. japonicus, finding RNAi is essential and involved in both post-transcriptional silencing and heterochromatin assembly.

PLoS Genetics · Feb 28, 2022Peer-reviewedMolecular Biology

De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

Roza H. Ali Masalmeh, Francesca Taglini, Cristina Rubio-Ramon, Kamila Irena Musialik, Jonathan Higham, Hazel Davidson‐Smith, Ioannis Kafetzopoulos, Kamila P. Pawlicka, Hannah Finan, Richard C. Clark, Jimi C. Wills, Andrew J. Finch, Lee Murphy, Duncan Sproul

The paper shows de novo DNA methyltransferases in colorectal cancer target H3K36me3-marked CpG islands, similar to normal tissues, rather than sequence-specific CpG islands.

Nature Communications · Jan 29, 2021Peer-reviewedGenetics