Cláudia Cavadas

This study investigates the role of aging in Machado-Joseph disease by analyzing age-related markers in human and animal models, finding decreased lamins and ZMPSTE24 levels and nuclear abnormalities.

This study shows astrocytic AMPK links metabolic signals to hypothalamic circadian timing by regulating phosphoproteome organization and behavior.

This study investigates circadian rhythm disruptions in Machado-Joseph disease patients and preclinical models, finding impaired clock gene expression and disrupted activity and temperature rhythms.

This study shows that soft extracellular matrix reduces autophagic flux and disrupts redox balance in neuronal cells, mimicking neurodegenerative disease features.