BiochemistrybioRxivPreprint
Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation
Janine L. Gray, Elizabeth V. K. Ledger, Tiffany Suwatthee…·Edward W. Tate
The paper identifies IMP-2380, a potent NorA inhibitor that enhances antibiotic activity by stabilizing the outward-open conformation of the efflux pump.
DOI 10.1101/2025.08.19.671038