Author
University of DundeeORCID 0000-0002-5238-1314Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Irene Georgiou, Sandra O’Neill, Colin Robinson…·Duncan E. Scott
The paper investigates false positives in SARS-CoV-2 nsp3 protease HTS assays caused by metal contamination and identifies copper and palladium as primary contaminants.
Irene Georgiou, Colin Robinson, Sean N. O’Byrne…·Ian Hugh Gilbert
The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.
Sarah D. Davey, Josephine Forde-Thomas, Benjamin J. Hulme…·Karl F. Hoffmann
A cytochrome P450 humanised mouse model is used to study Schistosoma mansoni development, schistosomiasis, drug metabolism and drug efficacy.
Janine L. Gray, Elizabeth V. K. Ledger, Tiffany Suwatthee…·Edward W. Tate
The paper identifies IMP-2380, a potent NorA inhibitor that enhances antibiotic activity by stabilizing the outward-open conformation of the efflux pump.
De Lin, Lesley-Anne Pearson, Shamshad Ahmad…·Ian Hugh Gilbert
The paper identifies a novel false-positive mechanism in RapidFire mass spectrometry and develops a pipeline to detect and mitigate these false positives in drug discovery.