Elizabeth V. K. Ledger

This study shows human serum promotes Staphylococcus aureus biofilm formation and antibiotic tolerance through Geh lipase activity and wall teichoic acid synthesis.

The paper identifies IMP-2380, a potent NorA inhibitor that enhances antibiotic activity by stabilizing the outward-open conformation of the efflux pump.

This study shows that daptomycin resistance in Staphylococcus aureus reduces its virulence in Drosophila by increasing susceptibility to prophenoloxidase, not through reduced toxin production or immune evasion.

This study shows that mecA expression in Staphylococcus aureus reduces daptomycin susceptibility by affecting toxin production and lipid-mediated antibiotic inactivation.

This study identifies PBP4 as essential for serum-induced cell wall thickening and antibiotic tolerance in Staphylococcus aureus, showing that targeting PBP4 with cefoxitin can enhance daptomycin efficacy.