Matthew J. Johnson

The paper investigates how DNA double-strand breaks formed during replication are processed, finding asymmetrical resection and different requirements for repair pathways.

This study shows the DNA replication checkpoint facilitates relocation of collapsed CAG/CTG repeat forks to the nuclear periphery via kinetochore phosphorylation and microtubule recruitment in S. cerevisiae.

The paper investigates the repair mechanism of replication-dependent double-strand breaks in budding yeast using nCas9-induced nicks and identifies the role of homologous recombination and replication-coupled nucleosome assembly.

This study demonstrates that genetically engineered memory T cells can deliver enzyme replacement therapy for mucopolysaccharidosis type I, reducing GAG levels in multiple tissues for up to 22 weeks.

This study shows that long-range DNA end resection by Exo1 and Sgs1-Dna2 supports homologous recombination through checkpoint activation, not by generating extensive homology.