Katherine Williams

The paper identifies Grem1-expressing fibroblastic reticular cells as a source of FLT3L that supports dendritic cell homeostasis and function in lymph nodes.

The paper uses engineered human myoblasts to show that D4Z4 heterochromatin disruption and DUX4 network activation are key in FSHD.

The paper introduces LR-Split-seq, a long-read single-cell RNA-seq method, to study differential RNA isoform expression and validates it using mouse myoblast differentiation data.

The paper identifies muscle group-specific transcriptomic and DNA methylation differences in FSHD that relate to developmental patterning and disease susceptibility.

The paper uses RNA FISH to study DUX4 and its target gene expression dynamics in FSHD patient myocytes, revealing a unique expression pattern and self-sustaining target gene network.

The paper identifies gene regulatory networks driving macrophage polarization using bulk and single-cell RNA-seq and ATAC-seq data from HL-60-derived macrophages.

The paper uses single-nucleus RNA-seq to identify two distinct populations of FSHD2 myotube nuclei with different transcriptional profiles related to DUX4 expression.