Shan Jiang

Long-read sequencing of 81 human and mouse samples yields 200,000 full-length transcripts plus a triplet framework that separates promoter choice, splicing and 3' end use across tissues.

The paper identifies fetal cis-regulatory elements in the human genome using single-cell multi-omics analysis, revealing thousands of organ- and cell-type-specific regulatory elements.

The paper compares chromatin dynamics during stem cell differentiation in human and rat, finding higher conservation in definitive endoderm than neuronal progenitor cells.

The paper uses single-nucleus RNA-seq to identify two distinct populations of FSHD2 myotube nuclei with different transcriptional profiles related to DUX4 expression.

The paper uses intra-individual DNA methylation analysis in rat buccal cells to show that early-life adversity alters methylation patterns predictive of gene repression and upregulation of inflammation and cell-fate pathways.

The paper presents ChIP-seq data for 208 DNA-associated proteins in HepG2 cells, revealing occupancy patterns and DNA motifs, and distinguishing promoters from enhancers.