Author

Jonathan Chau

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Kyoko YokomoriiD· 3 shared Xiangduo KongiD· 3 shared Ali MortazaviiD· 2 shared Katherine WilliamsiD· 2 shared Nam Viet NguyeniD· 2 shared Rabi TawiliD· 2 shared Tohru KiyonoiD· 2 shared Alexander R. Ball· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenetics

Kyoko YokomoriORCID

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Author profile →

3 papers

Recent·Most cited

Engineered SMCHD1 and D4Z4 mutations reveal roles of D4Z4 heterochromatin disruption and feedforward DUX4 network activation in FSHD

Xiangduo Kong, Nam Viet Nguyen, Yumeng Li, Jasmine Sakr, Katherine Williams, Sheila Sharifi, Jonathan Chau, Altay Bayrakci, Seiya Mizuno, Satoru Takahashi, Tohru Kiyono, Rabi Tawil, Ali Mortazavi, Kyoko Yokomori

The paper uses engineered human myoblasts to show that D4Z4 heterochromatin disruption and DUX4 network activation are key in FSHD.

bioRxiv · Oct 14, 2022 · PreprintGenetics

Relationship of DUX4 and target gene expression in FSHD myocytes

Jonathan Chau, Xiangduo Kong, Nam Viet Nguyen, Katherine Williams, Miya Ball, Rabi Tawil, Tohru Kiyono, Ali Mortazavi, Kyoko Yokomori

The paper uses RNA FISH to study DUX4 and its target gene expression dynamics in FSHD patient myocytes, revealing a unique expression pattern and self-sustaining target gene network.

Human Mutation · Jan 27, 2021Peer-reviewedGenetics

The cohesin loader NIPBL interacts with pre-ribosomal RNA and treacle to regulate ribosomal RNA synthesis

Xiangduo Kong, Yen-Yun Chen, Jianhuang Lin, Ebony Flowers, Eric L. Van Nostrand, Steven M. Blue, Jonathan Chau, Christopher I-Hsing, Isaiah Mohr, Ryan Thai, Chengguo Yao, Alexander R. Ball, Richard Chien, Shimako Kawauchi, Rosaysela Santos, , Kyoko Yokomori

This study identifies NIPBL's interaction with RNA and treacle in regulating pre-rRNA transcription and nucleolar organization.

bioRxiv · Jun 4, 2019 · PreprintMolecular Biology